Publications

Cell villages and Dirichlet modeling map human cell fitness genetics

bioRxiv (Preprint)

Hanson C*, Derebenskiy T*, Rodriguez Vega A, Kamte YS, Fox RG, Lambing H, Allard P, Pimentel H, Wells MF

βIV spectrin abundancy, cellular distribution, and sensitivity to AKT/GSK3 regulation in schizophrenia

Molecular Psychiatry

Di Re J, Marini M, Hussain SI, Singh AK, Venkatesh A, Alshammari MA, Alshammari TK, Hamoud AA, Imami AS, Haghighijoo Z, Fularcyzk N, Stertz L, Hawes D, Mosebarger A, Jernigan J, Chaljub C, Nehme R, Walss-Bass C, Schulmann A, Vawter MP, McCullumsmith R, Damoiseaux RD, Limon A, Labate D, Wells MF, Laezza F

Biallelic loss-of-function variants in CACHD1 cause a novel neurodevelopmental syndrome with facial dysmorphism and multisystem congenital abnormalities

Genetics in Medicine

Scala M, Khan K, Beneteau C, Fox RG, von Hardenberg S, Khan A, Joubert M, Fievet L, Musquer M, LeVaillant C, Holsclaw JK, Lim D, Berking A-C, Accogli A, Giacomini T, Nobili L, Striano P, Zara F, Torella A, Nigro V, Cogné B, Salick MR, Kaykas A, Eggan K, Capra V, Bézieau S, Davis EE, Wells MF

Protocol for neurogenin-2-mediated induction of human stem cell-derived neural progenitor cells

STAR Protocols

Guss EJ, Sathe L, Dai A, Derebenskiy T, Vega AR, Eggan K, Wells MF

Natural variation in gene expression and Zika virus susceptibility revealed by villages of neural progenitor cells

Cell Stem Cell

Wells MF*, Nemesh J*, Ghosh S*, Mitchell JM*, Mello C, Meyer D, Raghunathan K, Tegtmeyer M, Hawes D, Neumann A, Worringer K, Raymond J, Kommineni S, Chan K, Ho D, Peterson B, Piccioni F, Nehme R, Eggan K, McCarroll S

C9orf72 suppresses systemic and neural inflammation induced by gut bacteria

Nature

Burberry A, Wells MF, Limone F, Couto A, Smith KS, Keaney J, Gillet G, van Gastel N, Wang J-Y, Pietilainen O, Qian M, Eggan P, Cantrell C, Mok J, Kadiu I, Scadden DT, Eggan K

Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD

Nature Neuroscience

Chen Q, Diester CA, Gao X, Guo B, Lynn-Jones T, Chen N, Wells MF, Liu R, Goard MJ, Dimidschstein J, Feng S, Shi Y, Liao W, Lu Z, Fishell G, Moore CI, Feng G

The Next 50 Years of Neuroscience

Journal of Neuroscience

Altimus CM, Marlin BJ, Charalambakis NE, Colon-Rodriquez A, Glover EJ, Izbicki P, Johnson A, Lourenco MV, Makinson RA, McQuail J, Obeso I, Padilla-Coreano N, Wells MF

Targeting Peripheral Somatosensory Neurons to Article Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models

Cell

Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, LehtinenMK, Feng G, Ginty DD

Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids

JoVE

Salick MR*, Wells MF*, Eggan K, Kaykas A

Genetic ablation of AXL does not protect human neural progenitor cells and cerebral organoids from Zika virus infection

Cell Stem Cell

Wells MF*, Salick MR*, Wiskow O, Ho D, Worringer K, Ihry R, Kommineni S, Bilican B, Klim JR, Kane LT, Kaykas A, and Eggan K

Thalamic reticular defects underlie ADHD-like behaviors in Ptchd1Y/- mice

Nature

Wells MF*, Wimmer R*, Schmitt I, Feng G, Halassa M

Mice with Shank3 mutations associated with ASD and schizophrenia display both shared and distinct defects

Neuron

Zhou Y, Kaiser T, Monteiro P, Zhang X, Van der Goes MS, Wang D, Barak B, Zeng M, Li C, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z, Feng G

Shank3 mutant mice display autistic-like behaviors and postsynaptic dysfunction

Nature

Peca J*, Feliciano C*, Ting J, Wang W, Wells MF, Fu Z, Feng G